Call for an instant quote
0345 90 80 161
Open Mon to Fri 09:00 - 17:30 | Sat 09:00 - 16:00 (GMT)
04 June 2014 08:43
Scientists say one in four smokers with the defective gene BRCA2 will develop lung cancer
New research has discovered that a quarter of smokers with the defective gene BRCA2 will suffer from lung cancer during their lives.
The mutated gene, which is found in 2% of humans, has been associated with ovarian cancer and breast cancer for some time but now scientists say those who have it are nearly twice as likely as other people to have cancer of the lungs.
Around 13% of the 10 million Brits who smoke develop the disease during their lives but the risk is 25% among those with the gene flaw, as many as 200,000 people.
The leader of the research, Professor Richard Houlston, said that for smokers with the defective gene the risks of lung cancer are huge. The academic from the Institute of Cancer Research in London said the disease kills more people in Britain than any other cancer and as many as a million people around the world every year. The best way to prevent it is not smoking but it is even more crucial for people with the BRCA2 flaw, he said.
The study of 17,000 people across Europe, some with lung cancer and some without, looked for key differences and discovered a clear link between the disease and those participants with the c.9976T alteration to the BRCA2 gene. The connection was even more evident in those suffering from the most common type of the disease, known as squamous cell lung cancer. The scientists also found a connection between squamous cell lung cancer and another gene called CHEK2. Those suffering from the disease can arrange cancer travel insurance to protect them while on holiday.
Professor Houlston and his team think the findings from the study, which have been revealed in the Nature Genetics journal, could change the way people with the BRCA2 gene and lung cancer are treated in the future.
Doctors treating cancer patients with the BRCA2 gene who have developed breast or ovarian cancer have had some success by giving them drugs known as PARP inhibitors, but it is not yet known how they affect lung cancer, which is usually a fatal condition.
17 January 2017
Stansted Airport has made a bid to become Britain's next hub for long-haul travel, as passengers are promised seamless connection facilities and baggage transfer.
13 January 2017
Long-term goals such as travelling more and visiting new places have come above healthy eating and changing jobs in a list of the top New Year's resolutions.
14 January 2017
Some of the biggest airports in the UK have been forced to cancel flights as snow and blizzard conditions sweep parts of the country.
Stress could be as significant a risk factor for heart attacks and strokes as smoking, drinking and overeating, new research shows.
24 December 2016
Planned strikes by British Airways cabin crew on Christmas Day and Boxing Day have been suspended amid continuing industrial unrest ahead of the weekend break.
11 January 2017
A connection between diabetes and inflection in children could be a major breakthrough in developing a cure for type 1 diabetes, according to new research.
10 January 2017
A new trial aimed at tackling widespread loneliness among older people is successfully reducing isolation using community-based tactics, a report shows.
07 January 2017
People may be able to enjoy better brain health in later life by following a Mediterranean diet, research has suggested.
06 January 2017
Many Britons plan to cut down on the costs of their holidays in 2017, as part of their financial resolutions for the New Year.
05 January 2017
Holidaymakers have been encouraged to make the most of the fact 2017 boasts a pair of bank holiday weekends just two weeks apart.
04 January 2017
Holidaymakers are increasingly turning their attentions to trips which are all-inclusive, new research has suggested.
31 December 2016
Budget airline Norwegian has said it will launch ultra-low cost flights for as little at £56 to New York as it ramps up the pressure on its rivals.