Call for an instant quote
0345 90 80 161
Open Mon to Fri 09:00 - 17:30 | Sat 09:00 - 16:00 (GMT)
15 April 2014 09:29
Researchers claim the enzyme could be a useful target when it comes to treating asthma and boosting the effects of certain cancer therapies
Scientists have identified an enzyme that could be a useful target in treating asthma and boosting the effects of certain cancer therapies.
SKG1, which is involved in the regulation of immune system T cells, could hold the key to fine-tuning immune responses in patients.
In experiments involving laboratory mice, researchers at the Johns Hopkins Kimmel Cancer Center in the United States found that mice without the enzyme SKG1 were resistant to dust mite-induced asthma.
They also discovered that mice with melanoma and missing the enzyme developed far fewer lung tumours - less than half as many - than mice with SKG1.
Professor Jonathan Powell, lead author of the study, is excited at the prospect of a SKG1-blocking drug.
"If we can develop a drug that blocks the enzyme in a way that mimics what happens when the enzyme is missing, we would not only have a treatment to inhibit asthma, but also a drug that could be used in conjunction with other experimental therapies aimed at helping the immune system fight cancer," he said.
"We're not suppressing or exacerbating the immune system, we're regulating it. We're regulating it to do exactly what we want it to do."
SKG1 was also found to promote the production of T helper 2 cells, which become overactive in asthma and other allergies in a sort of runaway case of inflammation.
Finding a drug that could shut down SKG1 could therefore help block the inflammation that causes asthma and other allergic reactions.
Pre-existing medical travel insurance means people suffering from conditions like asthma and cancer can enjoy holidays without worrying.
cancer travel insurance, offers peace of mind whether you are a cancer survivor or are undergoing treatment for cancer.
24 February 2017
Heathrow airport has issued delay and cancellation warnings, after Storm Doris reached nearly 90mph on its way to batter Britain.
23 February 2017
Bowel cancer could be cut by more than a third amid the development of a one-off screening test, new research suggests.
22 February 2017
Hundreds of thousands of people with a potentially fatal genetic blood condition have yet to be diagnosed with the condition, a charity is warning.
21 February 2017
New technology to provide detailed scans of patients could improve the recovery of people suffering with liver cancer, scientists have said.
18 February 2017
At least 10 Britons have been injured in a speedboat accident off the icy coast of Norway.
17 February 2017
Comedian David Baddiel is trying to highlight the "epidemic" of dementia as a killer of older people in a new documentary.
16 February 2017
The public has spoken and the world's favourite cruises are being honoured by a top cruise review site.
15 February 2017
The collaborative #SkiSafe campaign has been relaunched in a bid to raise safety awareness among winter sports enthusiasts.
14 February 2017
A new "age defying" hormone could offer a breakthrough in preventing kidney and heart disease in people who suffer from diabetes.
11 February 2017
Patients needing new life-saving medication could have to wait two years after the UK leaves the EU, experts are warning.
10 February 2017
Families looking to take a cheap break in the upcoming half term are often sorely disappointed, however new research suggests Cyprus is the best destination for a well-priced trip.
09 February 2017
Europe remains the world's number one region as a travel destination - but tourism growth is slowing down, a travel industry report has said.