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Exercise hormone could help Alzheimer's patients

09 January 2019 08:20

Research suggests irisin could boost brain health

Research suggests irisin could boost brain health

A hormone released during exercise could help protect the brain from Alzheimer's disease, new research suggests.

Irisin, a messenger protein generated by muscle tissue that's carried around the body in the bloodstream, may be behind the positive effect on mental performance exercise has.

Scientists from the US and Brazil found lower levels of the hormone in the brains of Alzheimer's patients compared with healthy individuals. The same was true for the precursor protein from which irisin is derived, FNDC5.

Preventing cognitive decline

In tests on genetically engineered mice, scientists induced learning and memory deficits by cutting out irisin. They were able to reverse these effects by restoring the hormone.

When irisin signalling was blocked in mice with a rodent version of Alzheimer's, the brain benefits of physical exercise were lost. The research, led by Dr Fernana de Felice, from the Federal University of Rio de Janeiro in Brazil, is reported in the journal Nature Medicine.

Bolstering irisin, either with drugs or through exercise, could provide a "novel strategy" for preventing cognitive decline in patients with Alzheimer's disease, said the scientists.

They wrote: "Our results demonstrate that FNDC5/irisin levels are reduced in human AD (Alzheimer's disease) brains and CSF (cerebrospinal fluid) and in AD mouse models, and that boosting either brain or peripheral FNDC5/irisin levels attenuates synaptic and memory impairments in AD mouse models."

Further research was needed to understand exactly how irisin enters the brain and interacts with it, the team added.

British experts pointed out that the research, though promising, was at a very early stage.

Benefits of physical activity

Dr Rosa Sancho, from the charity Alzheimer's Research UK, said: "We know that physical activity is linked to better brain health as we age, and this research highlights a biological mechanism that may contribute to this beneficial effect.

"These interesting findings present a new avenue for future research that could help us better understand how exercise programmes could be targeted to provide the greatest benefit to brain health.

"There are many people either with dementia or at high risk of dementia, who have health conditions that make regular exercise more difficult.

"Drugs designed to target the hormone identified in this research could potentially bring some of the benefits of physical activity to people who may be less able to exercise."

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